Search results for "Nursing home residents"

showing 3 items of 3 documents

B and T cell immune responses elicited by the Comirnaty® COVID-19 vaccine in nursing home residents

2021

Objectives The immunogenicity of the Comirnaty® COVID-19 vaccine is understudied in elderly people with comorbidities. SARS-CoV-2-S-targeted antibody and T cell responses following full vaccination were assessed in nursing home residents. Methods Sixty nursing home residents (44 female; age, 53-100 years), of whom 10 had previously been diagnosed of COVID-19, and 18 healthy controls (15 female; age, 27-54 years) were recruited. Pre- and post-vaccination blood specimens were available for quantitation of total antibodies binding SARS-CoV-2 S protein and enumeration of SARS-CoV-2-S-reactive IFN-γ CD4+ and CD8+ T cells by flow cytometry. Results The seroconversion rate in presumably SARS-CoV-2…

AdultMale0301 basic medicineMicrobiology (medical)COVID-19 VaccinesSARS-CoV-2-S antibodiesT-LymphocytesT cell030106 microbiologyNursing home residentsAntibodies ViralFlow cytometryInterferon-gamma03 medical and health sciences0302 clinical medicineImmune systemComirnaty®COVID-19 vaccinemedicineHumans030212 general & internal medicineSeroconversionAgedAged 80 and overB-Lymphocytesbiologymedicine.diagnostic_testbusiness.industrySARS-CoV-2ImmunogenicityImmunityCOVID-19General MedicineMiddle AgedNursing HomesVaccinationInfectious Diseasesmedicine.anatomical_structureSARS-CoV-2-S T cellsSpike Glycoprotein CoronavirusImmunologybiology.proteinFemaleOriginal ArticleAntibodybusinessCD8Clinical Microbiology and Infection
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Immunological response against SARS-CoV-2 following full-dose administration of Comirnaty® COVID-19 vaccine in nursing home residents

2022

6 páginas, 2 figuras, 3 tablas. Se puede acceder al texto completo de este artículo desde PubMedCentral: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490129 . Los datos de investigación utilizados en el mismo, se encuentran disponibles en: https://doi.org/10.1016/j.cmi.2021.09.031.

MaleMicrobiology (medical)medicine.medical_specialtyCOVID-19 VaccinesSARS-CoV-2-S antibodiesFingerstickSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Nursing home residentsCD8-Positive T-LymphocytesAntibodies ViralImmune systemComirnaty®COVID-19 vaccineInternal medicinemedicineHumansProspective StudiesProspective cohort studyAgedAged 80 and overVenipuncturebiologybusiness.industrySARS-CoV-2COVID-19General MedicineNursing HomesVaccinationInfectious Diseasesbiology.proteinFemaleOriginal ArticleAntibodybusinessCD8
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EQ-5D-3L for Assessing Quality of Life in Older Nursing Home Residents with Cognitive Impairment

2020

Background: Quality of life (QoL) is recognized as an important patient-reported outcome measure. Assessing QoL in older people with cognitive impairment is a challenge due to discrepancies in the collection of data via proxies versus self-report. This study aimed to assess the psychometric properties of the self-reported EQ-5D (including the EQ index and EQ visual analog scale (VAS)) in nursing homes residents with cognitive impairment and to analyze its validity based on scales included in the comprehensive geriatric assessment. Methods: Cross-sectional, multicenter study analyzing the feasibility, acceptability, reliability, and validity of the EQ-5D based on 251 self-administered questi…

medicine.medical_specialtyVisual analogue scaleArticleGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciences0302 clinical medicineQuality of lifeCronbach's alphaEQ-5Dmeasurement propertiesEQ5DMedicine030212 general & internal medicinelcsh:ScienceCognitive impairmentcognitive functionEcology Evolution Behavior and Systematicsnursing home residentsbusiness.industryPaleontologyCognitionquality of lifeSpace and Planetary ScienceScale (social sciences)Physical therapylcsh:QNursing homesbusiness030217 neurology & neurosurgeryLife
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